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Sero-Surveillance to Assess Immunity to Rubella and Assessment of Immunogenicity and Safety of a Single dose of Rubella Vaccine in School Girls.
- Source :
- Indian Journal of Community Medicine; Jan2010, Vol. 35 Issue 1, p134-137, 4p, 2 Graphs
- Publication Year :
- 2010
-
Abstract
- Background: Rubella vaccination is not yet included in National Immunization Schedule in India. Serosurvey is frequently used to assess epidemiologic pattern of Rubella in a community. Serosurveys in different parts of India have found that 6-47% of women are susceptible for Rubella infection. The present serosurveillance was conducted in Jammu, India, in two public schools. Objective: To determine serological status of Rubella antibodies of school girls and assessment of immunogenicity and reactogenicity of Rubella immunization in seronegative girls. Materials and Methods: The current study was conducted to determine Rubella serostatus in peripubertal schoolgirls aged 11-18 years and also to assess immunogenicity and safety of Rubella vaccine (R-Vac) of Serum Institute of India Ltd., Pune, in seronegative girls. For screening, pre-vaccination serum Rubella IgG antibodies were determined and to assess immunogenicity of the vaccine, post-vaccination IgG antibodies were compared with pre-vaccination levels. Safety assessment was done for a period of 8 weeks, post-vaccination. Results: A total of 90 (32.7%) seronegative girls were vaccinated. All girls (100%) became seropositive, post-vaccination. Clinically relevant and statistically significant increase in anti-Rubella IgG titres was observed. The adverse events were mild and self-limiting. Conclusions: R-Vac vaccine used in the study demonstrated an excellent safety and immunogenicity profile. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGENETICS
RUBELLA vaccines
SCHOOLGIRLS
RUBELLA virus
SEROLOGY
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 09700218
- Volume :
- 35
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Indian Journal of Community Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 50334069
- Full Text :
- https://doi.org/10.4103/0970-0218.62575