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The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV-1 Infection.
- Source :
- Journal of Infectious Diseases; 5/1/2010, Vol. 201 Issue 9, p1298-1302, 5p
- Publication Year :
- 2010
-
Abstract
- Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4<superscript>+</superscript> T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 201
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 50612598
- Full Text :
- https://doi.org/10.1086/651664