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PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.
- Source :
- Nature Immunology; Jun2010, Vol. 11 Issue 6, p535-542, 8p, 7 Graphs
- Publication Year :
- 2010
-
Abstract
- Memory B and plasma cells (PCs) are generated in the germinal center (GC). Because follicular helper T cells (T<subscript>FH</subscript> cells) have high expression of the immunoinhibitory receptor PD-1, we investigated the role of PD-1 signaling in the humoral response. We found that the PD-1 ligands PD-L1 and PD-L2 were upregulated on GC B cells. Mice deficient in PD-L2 (Pdcd1lg2<superscript>−/−</superscript>), PD-L1 and PD-L2 (Cd274<superscript>−/−</superscript>Pdcd1lg2<superscript>−/−</superscript>) or PD-1 (Pdcd1<superscript>−/−</superscript>) had fewer long-lived PCs. The mechanism involved more GC cell death and less T<subscript>FH</subscript> cell cytokine production in the absence of PD-1; the effect was selective, as remaining PCs had greater affinity for antigen. PD-1 expression on T cells and PD-L2 expression on B cells controlled T<subscript>FH</subscript> cell and PC numbers. Thus, PD-1 regulates selection and survival in the GC, affecting the quantity and quality of long-lived PCs. [ABSTRACT FROM AUTHOR]
- Subjects :
- PLASMA cells
GERMINAL centers
B cells
T cells
CELL death
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 11
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 50723331
- Full Text :
- https://doi.org/10.1038/ni.1877