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Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages.
- Source :
- Archives of Pharmacal Research; Aug1998, Vol. 21 Issue 4, p481-484, 4p
- Publication Year :
- 1998
-
Abstract
- In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02536269
- Volume :
- 21
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Archives of Pharmacal Research
- Publication Type :
- Academic Journal
- Accession number :
- 51627254
- Full Text :
- https://doi.org/10.1007/BF02974648