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Immune cell crosstalk in type 1 diabetes.
- Source :
- Nature Reviews Immunology; Jul2010, Vol. 10 Issue 7, p501-513, 13p, 3 Diagrams, 2 Charts
- Publication Year :
- 2010
-
Abstract
- The development of type 1 diabetes involves a complex interaction between pancreatic beta-cells and cells of both the innate and adaptive immune systems. Analyses of the interactions between natural killer (NK) cells, NKT cells, different dendritic cell populations and T cells have highlighted how these different cell populations can influence the onset of autoimmunity. There is evidence that infection can have either a potentiating or inhibitory role in the development of type 1 diabetes. Interactions between pathogens and cells of the innate immune system, and how this can influence whether T cell activation or tolerance occurs, have been under close scrutiny in recent years. This Review focuses on the nature of this crosstalk between the innate and the adaptive immune responses and how pathogens influence the process. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL communication
DIABETES
PANCREATIC beta cells
IMMUNE system
KILLER cells
AUTOIMMUNITY
PATHOGENIC microorganisms
IMMUNE response
ANIMAL experimentation
BIOLOGICAL models
COMPARATIVE studies
DENDRITIC cells
IMMUNITY
IMMUNOLOGY technique
INFECTION
ISLANDS of Langerhans
TYPE 1 diabetes
LYMPHOCYTES
RESEARCH methodology
MEDICAL cooperation
MICE
RATS
RESEARCH
T cells
EVALUATION research
DISEASE complications
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 10
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 51667888
- Full Text :
- https://doi.org/10.1038/nri2787