Inhibition of Synovial Hyperplasia, Rheumatoid T Cell Activation, and Experimental Arthritis in Mice by Sulforaphane, a Naturally Occurring Isothiocyanate.

The article focuses on a study which investigated if sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, regulates synoviocyte hyperplasia and T cell activation in rheumatoid arthritis (RA). Study authors analyzed synoviocyte survival, levels of Bcl-2, Bax, p53, and pAkt, and cytokine concentrations in culture supernatants from mononuclear cells. They found that SFN inhibit synovial hyperplasia, activate T cell proliferation and the production of interleukin (IL)-17 and tumor necrosis factorα.