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Synthesis and calming activity of helicid derivatives containing the 3,4-dihydropyrimidin-2( H)-one and 3,4-dihydropyrimidine-2( H)-thione moiety.
- Source :
- Chemistry of Natural Compounds; Jul2010, Vol. 46 Issue 3, p412-416, 5p, 1 Diagram, 1 Chart
- Publication Year :
- 2010
-
Abstract
- A series of novel helicid derivatives containing 3,4-dihydropyrimidin-2(1 H)-one and 3,4-dihydropyrimidine2(1 H)-thione moiety ( 3a–3f and 4a–4f) were synthesized starting from helicid. The structure of the new compounds were characterized by <superscript>1</superscript>H NMR, IR and HR-MS spectra. The sedative-hypnotic activities of the target compounds were evaluated using the test of spontaneous locomotor activity in mice. All of the derivatives produced moderate to high activities; in particular, compound 4a presented the most potent sedative-hypnotic effect in comparison to the other derivatives, and derivatives 3a, 3c, 3d, 3e and 3f also showed potent activities. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANIMAL locomotion
HELICIDAE
HYPNOTICS
LABORATORY mice
SPECTRUM analysis
ALDEHYDES
Subjects
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 46
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 52191326
- Full Text :
- https://doi.org/10.1007/s10600-010-9630-5