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Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation.
- Source :
- Tissue Antigens; Sep99, Vol. 54 Issue 3, p229, 6p, 5 Charts, 2 Graphs
- Publication Year :
- 1999
-
Abstract
- Matching of human platelet alloantigen (HPA) systems 2–6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient’s survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD. [ABSTRACT FROM AUTHOR]
- Subjects :
- BONE marrow transplantation
ANTIGENS
HLA histocompatibility antigens
Subjects
Details
- Language :
- English
- ISSN :
- 00012815
- Volume :
- 54
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Tissue Antigens
- Publication Type :
- Academic Journal
- Accession number :
- 5220663
- Full Text :
- https://doi.org/10.1034/j.1399-0039.1999.540303.x