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Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
- Source :
- Nature Genetics; Aug2010, Vol. 42 Issue 8, p655-657, 3p, 1 Chart, 1 Graph
- Publication Year :
- 2010
-
Abstract
- We genotyped individuals with primary biliary cirrhosis and unaffected controls for suggestive risk loci (genome-wide association P < 1 × 10<superscript>−4</superscript>) identified in a previous genome-wide association study. Combined analysis of the genome-wide association and replication datasets identified IRF5-TNPO3 (combined P = 8.66 × 10<superscript>−13</superscript>), 17q12-21 (combined P = 3.50 × 10<superscript>−13</superscript>) and MMEL1 (combined P = 3.15 × 10<superscript>−8</superscript>) as new primary biliary cirrhosis susceptibility loci. Fine-mapping studies showed that a single variant accounts for the IRF5-TNPO3 association. As these loci are implicated in other autoimmune conditions, these findings confirm genetic overlap among such diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 42
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 52533862
- Full Text :
- https://doi.org/10.1038/ng.631