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Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells.
- Source :
- Journal of Biomedicine & Biotechnology; 2010, p1-12, 12p, 2 Diagrams, 1 Chart
- Publication Year :
- 2010
-
Abstract
- The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER cells
CLONE cells
ANTIGENS
T cells
LYMPHOCYTES
CELL-mediated cytotoxicity
Subjects
Details
- Language :
- English
- ISSN :
- 11107243
- Database :
- Complementary Index
- Journal :
- Journal of Biomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 53271246
- Full Text :
- https://doi.org/10.1155/2010/752381