Potential Th1/Th2 predominance in children with newly diagnosed IgA nephropathy.

The article presents a research study which investigated the role of Th1/Th2 proinflammatory cytokines in the development and progression of IgA nephropathy (IgAN) in children. It studied seven children with freshly diagnosed IgAN and mRNA expression was studied on urine samples. The study suggested that Th1 polarity might be involved in the pathogenesis of IgAN. It theoretically speculated that measuring the expressions of T-bet/GATA3 genes might provide clue pathogenic mechanisms of IgAN.