Genetic Variation in the RANKL/RANK/OPG Signaling Pathway Is Associated With Bone Turnover and Bone Mineral Density in Men.

The article discusses a study which determined the link of genetic variation in the RANKL/RANK/OPG signaling pathway with bone turnover and bone mineral density (BMD) in men. The researchers selected pairwise tag single-nucleotide polymorphisms (SNPs) in RANKL, RANK and OPG and their flanking regions. The results of the study suggest that genetic variation in the RANKL/RANK/OPG signaling pathway has an effect on bone turnover and BMD in European men.