Animal Models of Orthopoxvirus Infection.

Authors :: Chapman, J. L.
Nichols, D. K.
Martinez, M. J.
Raymond, J. W.
Source :: Veterinary Pathology; Sep2010, Vol. 47 Issue 5, p852-870, 19p, 2 Color Photographs, 5 Diagrams, 1 Chart
Publication Year :: 2010
Abstract: This article reviews the pathology of Orthopoxvirus infection in humans and animal models. Smallpox is a human disease caused by Variola virus, a species of Orthopoxvirus. Orthopoxviruses are double-stranded DNA viruses that replicate in the cytoplasm of cells and have a high degree of antigenic similarity. Monkeypox virus has been studied in rhesus and cynomolgus macaque as well as in several rodent species.