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Beneficial Effect of Caffeic Acid Phenethyl Ester (CAPE) on Hepatocyte Damage Induced by Bile Duct Ligation: An Electron Microscopic Examination.
- Source :
- Ultrastructural Pathology; Oct2010, Vol. 34 Issue 5, p273-278, 6p, 3 Black and White Photographs
- Publication Year :
- 2010
-
Abstract
- Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury. [ABSTRACT FROM AUTHOR]
- Subjects :
- ORGANIC compounds
BILE ducts
CYTOPLASM
RATS
LIVER cells
MITOCHONDRIAL pathology
Subjects
Details
- Language :
- English
- ISSN :
- 01913123
- Volume :
- 34
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Ultrastructural Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 54301214
- Full Text :
- https://doi.org/10.3109/01913121003788729