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Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.

Authors :
Stevens, David R.
Seifert, Reinhard
Bufe, Bernd
Muller, Frank
Kremmer, Elisabeth
Gauss, Renate
Meyerhof, Wolfgang
Kaupp, U. Benjamin
Lindemann, Bernd
Source :
Nature; 10/11/2001, Vol. 413 Issue 6856, p631, 5p, 8 Color Photographs, 15 Diagrams, 9 Graphs
Publication Year :
2001

Abstract

Examines the effects of sour stimuli on taste cells in slices of vallate papilla from rat. Identification of a hyperpolarization-activated current that was enhanced by sour stimulation at the taste pore; Dose-dependent flattening of the activation of curve of cyclic-nucleotide-gated channels caused by lowering extracellular pH.

Subjects

Subjects :
CYCLIC nucleotides
TASTE

Details

Language :
English
ISSN :
00280836
Volume :
413
Issue :
6856
Database :
Complementary Index
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
5500746
Full Text :
https://doi.org/10.1038/35098087