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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.
- Source :
- Nature Reviews Neuroscience; Dec2010, Vol. 11 Issue 12, p791-797, 7p, 2 Diagrams
- Publication Year :
- 2010
-
Abstract
- Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene--leucine-rich repeat kinase 2 (LRRK2)--affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1471003X
- Volume :
- 11
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Nature Reviews Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 55274612
- Full Text :
- https://doi.org/10.1038/nrn2935