Back to Search
Start Over
Tunable Chemokine Production by Antigen Presenting Dendritic Cells in Response to Changes in Regulatory T Cell Frequency in Mouse Reactive Lymph Nodes.
- Source :
- PLoS ONE; 2009, Vol. 4 Issue 11, p1-9, 9p
- Publication Year :
- 2009
-
Abstract
- The article presents a study investigating the secretion of tunable chemokine by antigen presenting dendritic cells in response to changes in frequency of regulatory T cells (Tregs) in mouse reactive lymph nodes (LN). As mentioned, using photon laser microscopy it is found that pro-inflammatory chemokines CCL2 (MCP-1) and CCL3 (MIP-la) are secreted in the LN early after T cell activation, as this secretion is dependent on antigen-specific DC-T cell interactions. It is also mentioned that secretion is inversely related to the frequency of Tregs specific for the same antigen.
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 4
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 56439065
- Full Text :
- https://doi.org/10.1371/journal.pone.0007696