Tunable Chemokine Production by Antigen Presenting Dendritic Cells in Response to Changes in Regulatory T Cell Frequency in Mouse Reactive Lymph Nodes.

The article presents a study investigating the secretion of tunable chemokine by antigen presenting dendritic cells in response to changes in frequency of regulatory T cells (Tregs) in mouse reactive lymph nodes (LN). As mentioned, using photon laser microscopy it is found that pro-inflammatory chemokines CCL2 (MCP-1) and CCL3 (MIP-la) are secreted in the LN early after T cell activation, as this secretion is dependent on antigen-specific DC-T cell interactions. It is also mentioned that secretion is inversely related to the frequency of Tregs specific for the same antigen.