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Three Distinct Domains Contribute to Nuclear Transport of Murine Foxp3.
- Source :
- PLoS ONE; 2009, Vol. 4 Issue 11, p1-6, 6p
- Publication Year :
- 2009
-
Abstract
- The article presents a study related to the nuclear transport of murine Foxp3. Foxp3 refers to a 47-kDa transcription factor, which is required for the function of CD4+CD25+ regulatory T cells (Tregs). The study involves the identification of three distinct Foxp3 domains which contribute to nuclear transport. The first domain consists of C-terminal 12 amino acids, while the second one is located immediately N-terminal to the forkhead domain (FHD). The third domain's location is within the N-terminal first 51 amino acids.
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 4
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 56439257
- Full Text :
- https://doi.org/10.1371/journal.pone.0007890