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Seven-year response to imatinib as initial treatment versus re-treatment in Chinese patients with chronic myelogenous leukemia in the chronic phase.
- Source :
- Annals of Hematology; Jan2011, Vol. 90 Issue 1, p41-46, 6p, 1 Chart, 5 Graphs
- Publication Year :
- 2011
-
Abstract
- The purpose of our study is to compare the 7-year response to imatinib monotherapy as an initial treatment and re-treatment in Chinese patients with chronic myelogenous leukemia-chronic phase (CML-CP) patients in a single center in Beijing. A retrospective study of 171 CML-CP patients receiving imatinib monotherapy was done with 73 in the initial treatment group (disease course ≤6 months) and 98 in the re-treatment group (disease course >6 months). Cumulative rates of complete cytogenetic response (CCyR) at 6, 12, and 36 months after imatinib treatment in the initial and re-treatment groups were 75%, 89%, and 96%, and 48%, 77% and 84% ( p = 0.0002), respectively. The median time to CCyR in the initial and re-treatment groups was 6 months (95% CI, 3.3-8.3) and 9 months (95% CI, 6.4-11.6), respectively ( p = 0.0002). Cumulative rates of major molecular responses at 9, 12, and 18 months after imatinib treatment in the initial and re-treatment groups were 31%, 48%, and 60%, and 15%, 25% and 37% (p = 0.017), respectively. The median time to the major molecular response in the initial and re-treatment groups was 15 months (95% CI, 12.3-17.7) and 36 months (95% CI, 25.9-46.0), respectively ( p = 0.017). Progression-free survival at 84 months in the initial and re-treatment groups was 97% and 85%, respectively ( p = 0.09). Event-free survival at 84 months in the initial and re-treatment groups was 92% and 70%, respectively ( p = 0.049). Only two of the 171 patients discontinued imatinib therapy for grade 3/4 adverse events. Our study revealed that CML-CP patients would benefit from early treatment with imatinib. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMATINIB
CHRONIC myeloid leukemia
CYTOGENETICS
MEDICAL care
Subjects
Details
- Language :
- English
- ISSN :
- 09395555
- Volume :
- 90
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 56788493
- Full Text :
- https://doi.org/10.1007/s00277-010-1031-0