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Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy.
- Source :
- IUBMB Life; Jan2011, Vol. 63 Issue 1, p54-61, 8p, 2 Black and White Photographs, 2 Graphs
- Publication Year :
- 2011
-
Abstract
- Myocardin is a remarkably potent transcriptional coactivator expressed specifically in cardiac muscle lineages and smooth muscle cells during postnatal development. Myocardin shares homology with myocardin-related transcription factor-A (MRTF-A), which are expressed in a broad range of embryonic and adult tissues. Our previous results show that myocardin induces cardiac hypertrophy. However, the effects of MRTF-A in cardiac hypertrophy remain poorly understood. Our present work further demonstrates that myocardin plays an important role in inducing hypertrophy. At the same time, we find that overexpression of MRTF-A in neonatal rat cardiomyocytes might induce cardiomyocyte hypertrophy. Furthermore, MRTF-A expression is induced in phenylephrine, angiotensin-II, and transforming growth factor-β-stimulated cardiac hypertrophy, whereas a dominant-negative form of MRTF-A or MRTF-A siRNA strongly inhibited upregulation of hypertrophy genes in response to hypertrophic agonists in neonatal rat cardiomyocytes. Our studies indicate that besides myocardin, MRTF-A might play an important role in cardiac hypertrophy. Our findings provide novel evidence for the future studies to explore the roles of MRTFs in cardiac hypertrophy. © 2011 IUBMB IUBMB Life, 63(1):54-61, 2011. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15216543
- Volume :
- 63
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- IUBMB Life
- Publication Type :
- Academic Journal
- Accession number :
- 57656189
- Full Text :
- https://doi.org/10.1002/iub.415