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Evaluating Strategies for Marker Ranking in Genome-wide Association Studies of Complex Traits.

Authors :
Scherag, A.
Hebebrand, J.
Wichmann, H.-E.
Jöckel, K.-H.
Source :
Methods of Information in Medicine; 2010, Vol. 49 Issue 6, p632-640, 9p
Publication Year :
2010

Abstract

The article presents a study on the comparative statistical properties of genetic marker ranking which include False Positive Report Probability (FPRP), Bayesian False-Discovery Probability (BFDP), q-values, and p-values. The study employs simulation studies for genomic regions as well as the mean square errors in genome-wide association studies. The study showed the precision of BFDP and p-values in the reconstruction of true genetic markers in the region.

Details

Language :
English
ISSN :
00261270
Volume :
49
Issue :
6
Database :
Complementary Index
Journal :
Methods of Information in Medicine
Publication Type :
Academic Journal
Accession number :
57950148
Full Text :
https://doi.org/10.3414/ME09-02-0055