Synthesis, biological activity and solution structure of new analogues of the antimicrobial Gramicidin S.

The article examines the effects of perturbations imposed on the amphipatic moments of Gramicidin S (GS) cyclo-decapeptide analogues. Previous studies indicate that better antimicrobial selectivity is attained when the amphipatic moments of the analogues of GS-14 is perturbed. Structural studies of GS by molecular dynamics show a two-stranded antiparallel Β-sheets imposed by two Β-turns. The study concluded that the idea of perturbation on the amphipatic moment does not work for GS-10-0 analogues.