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Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study.
- Source :
- Cancer Causes & Control; Mar2011, Vol. 22 Issue 3, p503-510, 8p, 3 Charts
- Publication Year :
- 2011
-
Abstract
- <bold>Background: </bold>Coffee consumption has been associated with reduced markers of hepatic cell damage, reduced risk of chronic liver disease, and cirrhosis across a variety of populations. Data on the association between coffee consumption and risk of hepatocellular carcinoma (HCC), especially in high-risk populations, are sparse.<bold>Methods: </bold>This study examines the relationship between coffee and caffeine consumption, and the risk of developing HCC within the Singapore Chinese Health Study, a prospective cohort of 63,257 middle-aged and older Chinese men and women, a relatively high-risk population for HCC. Baseline data on coffee consumption and other dietary and lifestyle factors were collected through in-person interviews at enrollment between 1993 and 1998.<bold>Results: </bold>As of 31 December 2006, 362 cohort participants had developed HCC. High levels of coffee or caffeine consumption were associated with reduced risk of HCC (p for trend < 0.05). Compared with non-drinkers of coffee, individuals who consumed three or more cups of coffee per day experienced a statistically significant 44% reduction in risk of HCC (hazard ratio 0.56, 95% confidence interval, 0.31-1.00, p = .049) after adjustment for potential confounders and tea consumption.<bold>Conclusion: </bold>These data suggest that coffee consumption may reduce the risk of developing HCC in Chinese in Singapore. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09575243
- Volume :
- 22
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Cancer Causes & Control
- Publication Type :
- Academic Journal
- Accession number :
- 58508493
- Full Text :
- https://doi.org/10.1007/s10552-010-9725-0