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Preparation of Novel 2,3,8-Trisubstituted Pyrido[3,4-b]pyrazines and Pyrido[2,3-b]pyrazines.
- Source :
- Synthesis; 2011, Vol. 2011 Issue 5, p794-806, 13p
- Publication Year :
- 2011
-
Abstract
- A four-step synthesis of 8-bromo-2,3-disubstituted pyrido[ 3,4-b]pyrazines and a six-step synthesis of 8-amino-2,3-disubstituted pyrido[3,4-b]pyrazines have been developed. A particularly valuable feature of this synthetic route is the possibility to build 2,3- disubstituted pyrido[3,4-b]pyrazines with a large variety of substituents in position 8 (aniline, amide, urea, thiourea). Our protocol was extended to the synthesis of 2,3,8-trisubstituted pyrido[2,3-b]pyrazines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 2011
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 58656993
- Full Text :
- https://doi.org/10.1055/s-0030-1259429