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Methylation-mediated regulation of E2F1 in DNA damage-induced cell death.
- Source :
- Journal of Receptors & Signal Transduction; Apr2011, Vol. 31 Issue 2, p139-146, 8p, 5 Graphs
- Publication Year :
- 2011
-
Abstract
- E2F1 promotes DNA damage-induced apoptosis and the post-translational modifications of E2F1 play an important role in the regulation of E2F1-mediated cell death. Here, we found that Set9 and LSD1 regulate E2F1-mediated apoptosis upon DNA damage. Set9 methylates E2F1 at lysine 185, a conserved residue in the DNA-binding domain of E2F family proteins. The methylation of E2F1 by Set9 leads to the stabilization of E2F1 and up-regulation of its proapoptotic target genes p73 and Bim, and thereby induces E2F1-mediated apoptosis in response to genotoxic agents. We also found that LSD1 demethylates E2F1 at lysine 185 and reduces E2F1-mediated cell death. The identification of the methylation/demethylation of E2F1 by Set9/LSD1 suggests that E2F1 is dynamically regulated by epigenetic enzymes in response to DNA damage. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10799893
- Volume :
- 31
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Receptors & Signal Transduction
- Publication Type :
- Academic Journal
- Accession number :
- 59184432
- Full Text :
- https://doi.org/10.3109/10799893.2011.552914