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Effects of the anti-interleukin-6 receptor antibody, tocilizumab, on serum lipid levels in patients with rheumatoid arthritis.
- Source :
- Rheumatology International; Apr2011, Vol. 31 Issue 4, p451-456, 6p, 4 Charts, 1 Graph
- Publication Year :
- 2011
-
Abstract
- We investigated the effects of anti-IL-6 receptor antibody, tocilizumab (TCZ), on lipid metabolism. Nineteen patients with rheumatoid arthritis (RA), entered in clinical case-control study of SAMURAI trial at Sasebo Chuo Hospital, were examined. Nine patients received TCZ monotherapy at 8 mg/kg intravenously every 4 weeks (TCZ group) and 10 patients received conventional DMARDs (control group). Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), apolipoprotein (Apo) A-1, Apo A-2 and Apo B as well as disease activity score (DAS), C-reactive protein and serum amyloid A protein were examined at baseline and after 3 months of the treatment. IL-6 inversely was correlated with LDL, Apo A-1 and Apo A-2, and also tended to correlate with Apo B. In TCZ group, serum levels of TC, HDL, LDL, Apo A-1 and Apo A-2 were significantly increased after 3 months treatment with TCZ. There was no significant change in Apo B, the atherogenic index, and TC/HDL by the TCZ treatment. Changes in the DAS28-ESR negatively correlated with those in TC. In one patient, whose serum level of TCZ was not detected after 3 months of the treatment, the absence of the increment in serum levels of Apo A-1 and A-2 in the patient was remarkable. All of the markers did not change during 3 months in control group. These data may raise an important issue to evaluate the impact of these alternations in lipid metabolism for longer periods in RA patients treated with TCZ. [ABSTRACT FROM AUTHOR]
- Subjects :
- RHEUMATOID arthritis
AUTOIMMUNE diseases
BLOOD lipids
INTERLEUKIN-6
ISOPENTENOIDS
Subjects
Details
- Language :
- English
- ISSN :
- 01728172
- Volume :
- 31
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Rheumatology International
- Publication Type :
- Academic Journal
- Accession number :
- 59341820
- Full Text :
- https://doi.org/10.1007/s00296-009-1303-y