Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.

The article focuses on a study about the association between phosphorylated (p)-AKT expression with PIK3CA mutation and low stage and favorable prognosis of colorectal cancer. It relates the processes behind the study, one is the collection of tissue blocks from hospitals. Results of the study reinforce such association, leading to the suggestion that p-AKT can serve as a biomarker for outcomes and therapeutic targets. Factors behind the relationship between AKT activation and positive prognosis are discussed.