SiRNA delivery with exosome nanoparticles.

The article discusses a proposal by Alvarez-Erviti et al to deliver small interfering RNA (siRNA) by harnessing the body's own intercellular shuttle service for RNAs. It indicates that the use of exosomes as an siRNA carriers can be a major advance in the field of macromolecular drug delivery and a possible step toward clinical application of siRNA. It indicates that the group did not study whether RVG-Lamp2b fusion-protein induces adaptive immunity and did not address that the receptor used by RVG is decreased in brains affected by Alzhemer's disease.