Biological evaluation of CpG stimulation of normal human B-cells: implications for B-cell biology and cytogenetic analysis of CLL B-cells.

The article reports on the use of CpG oligodeoxynucleotides (CpG) in clinical laboratories as a mitogenic tool to reveal chromosomal abnormalities in malignant B-cells from chronic lymphocytic leukemia (CLL) patients . It reports on a study conducted to validate the role of CpG in revealing cytogenetic abnormalities in CLL B-cells. It also reports on a study conducted to validate whether CpG stimulated B-cells.