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Glutathione S-Transferase M1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) Null Polymorphisms, Smoking, and Their Interaction in Oral Cancer: A HuGE Review and Meta-Analysis.
- Source :
- American Journal of Epidemiology; Apr2011, Vol. 173 Issue 8, p847-857, 11p
- Publication Year :
- 2011
-
Abstract
- The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of the GSTM1 and GSTT1 genes and oral cancer. Twenty-eight case-control studies published in English were identified. Summary odds ratios were derived via random-effects models. The summary odds ratio for the GSTM1 null genotype was 1.43 in Asians (95% confidence interval (CI): 1.14, 1.78; P < 0.01, I 2 = 73%) and 0.98 in Caucasians (95% CI: 0.76, 1.28; P = 0.91, I 2 = 0%). Case-only analysis of 6 studies (552 cases) showed an inverse multiplicative interaction between GSTM1 null polymorphisms and smoking (ever/high levels of smoking vs. never/low levels) (odds ratio (OR) = 0.51, 95% CI: 0.32, 0.82; P = 0.01, I 2 = 34%). The GSTT1 null genotype was not significantly associated with oral cancer in Asians (OR = 1.07, 95% CI: 0.82, 1.38; P = 0.63, I 2 = 65%) or Caucasians (OR = 1.04, 95% CI: 0.41, 2.65; P = 0.93, I 2 = 55%). In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status. The GSTT1 null genotype may not be associated with oral cancer. [ABSTRACT FROM PUBLISHER]
- Subjects :
- MOUTH tumors
ASIANS
CONFIDENCE intervals
STATISTICAL correlation
EPIDEMIOLOGY
GENETIC polymorphisms
GLUTATHIONE
MATHEMATICAL models
MEDLINE
META-analysis
ONLINE information services
RESEARCH funding
SMOKING
STATISTICS
TRANSFERASES
WHITE people
EVIDENCE-based medicine
PROFESSIONAL practice
DATA analysis
TUMOR risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 173
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 59962272
- Full Text :
- https://doi.org/10.1093/aje/kwq480