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Safety and Immunogenicity of 4 Intramuscular Double Doses and 4 Intradermal Low Doses vs Standard Hepatitis B Vaccine Regimen in Adults With HIV-1: A Randomized Controlled Trial.
- Source :
- JAMA: Journal of the American Medical Association; 4/13/2011, Vol. 305 Issue 14, p1432-1440, 9p, 1 Diagram, 3 Charts, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- The article discusses a randomized controlled trial aimed at comparing the safety and immunogenicity of four intramuscular double-dose regimen and four intradermal low-dose regimen against the standard hepatitis B vaccine regimen in adults with human immunodeficiency virus 1 (HIV-1) infection. The trial was conducted in France from June 28, 2007 to October 23, 2008. The percentage of responders at the 28th week was defined as patients with hepatitis B surface antibody (anti-HBs) of at least 10 milli-international unit/milliliter (mIU/ml) in patients given at least one dose of vaccine. The trial found an improved serological response among patients in the four intramuscular double-dose and the four intradermal low-dose regimens compared with the standard HBV vaccine regimen.
- Subjects :
- RANDOMIZED controlled trials
HEPATITIS B vaccines
HIV
SEROLOGY
DRUG dosage
Subjects
Details
- Language :
- English
- ISSN :
- 00987484
- Volume :
- 305
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- JAMA: Journal of the American Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 59986095
- Full Text :
- https://doi.org/10.1001/jama.2011.351