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B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia.
- Source :
- Cancer (0008543X); 5/1/2011, Vol. 117 Issue 9, p1891-1900, 10p, 1 Diagram, 3 Charts, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- BACKGROUND: B-cell receptors (BCRs) and their recognition of specific epitopes may play a pivotal role in the development and progression of chronic lymphocytic leukemia (CLL). In this study, the authors set up a model system to explore epitope reactivity and its clinical relevance in CLL. METHODS: Epitope-mimicking peptides were selected from phage display libraries on 6 CLL BCRs from randomly chosen patients. The binding of the 6 index epitope mimics was evaluated in a set of 100 unrelated CLL samples. Epitope recognition patterns were correlated with the clinical course of the disease. RESULTS: Surprisingly, all CLL samples recognized 1 or several index epitopes, and some revealed marked polyreactivity. Patients with CLL who expressed BCRs that reacted with ≥5 epitope mimics had a significantly worse clinical course than less polyreactive patients (median time to first treatment, 24 months vs 102 months). This effect was independent of otherwise known prognostic markers. CONCLUSIONS: The authors introduced a system with which to model epitope reactivity of CLL BCRs without previous knowledge of potential antigens. The findings indicated that a polyreactive epitope recognition pattern may be a determinant of an aggressive clinical course in this disease. This further emphasizes the functional and prognostic relevance of BCR epitope recognition in CLL. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONIC lymphocytic leukemia
B cells
CELL receptors
PEPTIDES
EPITOPES
Subjects
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 117
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 60110611
- Full Text :
- https://doi.org/10.1002/cncr.25755