Association of CTNNB1 (β-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer.

The article focuses on a study on the association of wingless type (WNT)-cadherin-associated protein β1 (CTNNB1 or βcatenin) activation in colorectal cancer with changes in the prognostic associations of body mass index (BMI) and level of postdiagnosis physical activity. The study has involved data from the Nurses' Health Study and the Health Professionals Follow-up Study in which cohort participants received follow-up questionnaires on dietary and lifestyle factors and new cancer diagnosis. Results of the study are given, one is the association between the positive status for nuclear CTNNB1 and better cancer-specific and overall mortality in obese patients. It concludes that tumor cell behavior is influenced by CTNNB1 changes and energy balance status.