NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionineElectronic supplementary information (ESI) available: Experimental data, NMR spectra and chemical shifts and constraints data. See DOI: 10.1039/c1cc11600b

The first NMR structure of a Cu(i)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(i) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport. [ABSTRACT FROM AUTHOR]