Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.

Shows that viral escape from cytotoxic T lymphocyte (CTL) recognition can result in the eventual failure of this partial immune protection. Description of viral mutations that escape from CTL recognition in HIV-infected persons and SIV-infected monkeys; Frequency of viral sequence mutations within CTL epitopes; Limitations of the CTL-based AIDS vaccines.