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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
- Source :
- Nature; 1/17/2002, Vol. 415 Issue 6869, p335-339, 5p, 1 Diagram, 10 Graphs
- Publication Year :
- 2002
-
Abstract
- Shows that viral escape from cytotoxic T lymphocyte (CTL) recognition can result in the eventual failure of this partial immune protection. Description of viral mutations that escape from CTL recognition in HIV-infected persons and SIV-infected monkeys; Frequency of viral sequence mutations within CTL epitopes; Limitations of the CTL-based AIDS vaccines.
- Subjects :
- ANTINEOPLASTIC agents
MICROBIAL mutation
AIDS vaccines
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 415
- Issue :
- 6869
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 6134996
- Full Text :
- https://doi.org/10.1038/415335a