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Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma.
- Source :
- British Journal of Cancer; 6/20/2011, Vol. 105 Issue 1, p131-138, 8p, 1 Color Photograph, 2 Black and White Photographs, 3 Charts, 1 Graph
- Publication Year :
- 2011
-
Abstract
- <bold>Background: </bold>Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.<bold>Patients and Methods: </bold>One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Met(high) and c-Met(low) groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.<bold>Results: </bold>The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Met(high) expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Met(high) expression was significantly correlated with the 5-year survival rate for CC overall (P=0.0046) and for IHCC (P=0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Met(high) expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.<bold>Conclusions: </bold>c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHOLANGIOCARCINOMA
EPIDERMAL growth factor
CANCER patients
CELL lines
PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 105
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 61980970
- Full Text :
- https://doi.org/10.1038/bjc.2011.199