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Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.
- Source :
- Cell Communication & Signaling; 2011, Vol. 9 Issue 1, p13-30, 18p
- Publication Year :
- 2011
-
Abstract
- This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-κB, p53, and AKT pathways are summarized. [ABSTRACT FROM AUTHOR]
- Subjects :
- QUINACRINE
PHARMACOKINETICS
CYTOPLASM
PROTEINS
DRUG resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1478811X
- Volume :
- 9
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Cell Communication & Signaling
- Publication Type :
- Academic Journal
- Accession number :
- 62671669
- Full Text :
- https://doi.org/10.1186/1478-811X-9-13