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Screening of Bcr-Abl Transcripts in Philadelphia Negative Essential Thrombocythemia.
- Source :
- Leukemia & Lymphoma; Oct2000, Vol. 39 Issue 3/4, p339, 3p, 1 Chart
- Publication Year :
- 2000
-
Abstract
- Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterised by the absence of the Philadelphia (Ph+) chromosome. Recent studies have reported controversial results relating to BCR-ABL rearrangements in ET patients. We studied 44 Ph-negative ET patients with the RT-PCR technique at diagnosis or during the follow-up. None of them showed any of the BCR-ABL transcript actually described by others in ET; neither the “classical” P210 nor the P190 or P230 variants. Our results confirm the absence of BCR-ABL abnormalities in Ph-negative ET patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- THROMBOCYTOSIS
CHROMOSOMES
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 39
- Issue :
- 3/4
- Database :
- Complementary Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 6278159
- Full Text :
- https://doi.org/10.3109/10428190009065833