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Maternal exposure to household chemicals and risk of infant leukemia: a report from the Children's Oncology Group.
- Source :
- Cancer Causes & Control; Aug2011, Vol. 22 Issue 8, p1197-1204, 8p, 3 Charts
- Publication Year :
- 2011
-
Abstract
- <bold>Objective: </bold>Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infant acute leukemia.<bold>Methods: </bold>We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs).<bold>Results: </bold>We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy.<bold>Conclusions: </bold>Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09575243
- Volume :
- 22
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Cancer Causes & Control
- Publication Type :
- Academic Journal
- Accession number :
- 62911108
- Full Text :
- https://doi.org/10.1007/s10552-011-9798-4