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Expression of active Notch1 in avian coronary development.
- Source :
- Developmental Dynamics; Jan2009, Vol. 238 Issue 1, p162-170, 9p
- Publication Year :
- 2009
-
Abstract
- Notch1 is an important regulator of intercellular interactions in cardiovascular development. We show that the nuclear-localized, cleaved and active form of Notch1, the Notch1 intracellular domain (N1ICD), appeared in mesothelial cells of the pro-epicardium during epicardial formation at looped heart stages. N1ICD was also present in mesothelial cells and mesenchymal cells specifically within the epicardium at sulcus regions. N1ICD-positive endothelial cells were detected within the nascent vessel plexus at the atrioventricular junction and within the compact myocardium (Hamburger and Hamilton stage [HH] 25-HH30). The endothelial cells expressing N1ICD were surrounded by N1ICD-positive smooth muscle cells after coronary orifice formation (HH32-HH35), while N1ICD expression was absent in the mesenchymal and mesothelial cells surrounding mature coronary vessels. We propose that differential activation of the hypoxia/HIF1-VEGF-Notch pathway may play a role in epicardial cell interactions that promote epicardial epithelial/mesenchymal transition and coronary progenitor cell differentiation during epicardial development and coronary vasculogenesis in particularly hypoxic sulcus regions. Developmental Dynamics 238:162-170, 2009. © 2008 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10588388
- Volume :
- 238
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Developmental Dynamics
- Publication Type :
- Academic Journal
- Accession number :
- 63328134
- Full Text :
- https://doi.org/10.1002/dvdy.21811