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Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.

Authors :
Li, Aimin
Xing, Yiming
Chan, Belinda
Heisterkamp, Nora
Groffen, John
Borok, Zea
Minoo, Parviz
Li, Changgong
Source :
Developmental Dynamics; Aug2010, Vol. 239 Issue 8, p2288-2297, 10p
Publication Year :
2010

Abstract

Adenomatous polyposis coli (Apc) is critical for Wnt signaling and cell migration. The current study examined Apc expression during lung development, injury, and repair. Apc was first detectable in smooth muscle layers in early lung morphogenesis, and was highly expressed in ciliated and neuroendocrine cells in the advanced stages. No Apc immunoreactivity was detected in Clara or basal cells, which function as stem/progenitor cell in adult lung. In ciliated cells, Apc is associated mainly with apical cytoplasmic domain. In response to naphthalene-induced injury, Apc<superscript>positive</superscript> cells underwent squamous metaplasia, accompanied by changes in Apc subcellular distribution. In conclusion, both spatial and temporal expression of Apc is dynamically regulated during lung development and injury repair. Differential expression of Apc in progenitor vs. nonprogenitor cells suggests a functional role in cell-type specification. Subcellular localization changes of Apc in response to naphthalene injury suggest a role in cell shape and cell migration. Developmental Dynamics 239:2288-2297, 2010. © 2010 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10588388
Volume :
239
Issue :
8
Database :
Complementary Index
Journal :
Developmental Dynamics
Publication Type :
Academic Journal
Accession number :
63328556
Full Text :
https://doi.org/10.1002/dvdy.22364