Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNAElectronic supplementary information (ESI) available: Cartesian coordinates of the computed models. See DOI: 10.1039/c1cp20423h.

Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments. [ABSTRACT FROM AUTHOR]