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Gadolinium-conjugated PLA-PEG nanoparticles as liver targeted molecular MRI contrast agent.
- Source :
- Journal of Drug Targeting; Sep2011, Vol. 19 Issue 8, p657-665, 9p
- Publication Year :
- 2011
-
Abstract
- A nanoparticle magnetic resonance imaging (MRI) contrast agent targeted to liver was developed by conjugation of gadolinium (Gd) chelate groups onto the biocompatible poly( l-lactide)-block-poly (ethylene glycol) (PLA-PEG) nanoparticles. PLA-PEG conjugated with diethylenetriaminopentaacetic acid (DTPA) was used to formulate PLA-PEG-DTPA nanoparticles by solvent diffusion method, and then Gd was loaded onto the nanoparticles by chelated with the unfolding DTPA on the surface of the PLA-PEG-DTPA nanoparticles. The mean size of the nanoparticles was 265.9 ±± 6.7 nm. The relaxivity of the Gd-labeled nanoparticles was measured, and the distribution in vivo was evaluated in rats. Compared with conventional contrast agent (Magnevist), the Gd-labeled PLA-PEG nanoparticles showed significant enhancement both on liver targeting ability and imaging signal intensity. The T<subscript>1</subscript> and T<subscript>2</subscript> relaxivities per [Gd] of the Gd-labeled nanoparticles was 18.865 mM<superscript>−−1</superscript> s<superscript>−−1</superscript> and 24.863 mM<superscript>−−1</superscript> s<superscript>−−1</superscript> at 3 T, respectively. In addition, the signal intensity in vivo was stronger comparing with the Gd-DTPA and the T<subscript>1</subscript> weight time was lasting for 4.5 h. The liver targeting efficiency of the Gd-labeled PLA-PEG nanoparticles in rats was 14.57 comparing with Magnevist injection. Therefore, the Gd-labeled nanoparticles showed the potential as targeting molecular MRI contrast agent for further clinical utilization. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1061186X
- Volume :
- 19
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Drug Targeting
- Publication Type :
- Academic Journal
- Accession number :
- 64132535
- Full Text :
- https://doi.org/10.3109/1061186X.2010.531727