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White matter vascular lesions are related to parietal-to-frontal coupling of EEG rhythms in mild cognitive impairment.
- Source :
- Human Brain Mapping; Dec2008, Vol. 29 Issue 12, p1355-1367, 13p
- Publication Year :
- 2008
-
Abstract
- Do cerebrovascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI) as a putative preclinical stage of AD? Here we tested the hypothesis that directionality of fronto-parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white-matter vascular load was quantified based on magnetic resonance images (0-30 visual rating scale). EEG rhythms of interest were δ (2-4 Hz), θ (4-8 Hz), α1 (8-10.5 Hz), α2 (10.5-13 Hz), β1 (13-20 Hz), and β2 (20-30 Hz). Directionality of fronto-parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto-parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at θ, α1, α2, and β1 in MCI V+ (high vascular load; N = 42; MMSE = 26) than in MCI V− group (low vascular load; N = 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions. Hum Brain Mapp 2008. © 2007 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10659471
- Volume :
- 29
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Human Brain Mapping
- Publication Type :
- Academic Journal
- Accession number :
- 64316249
- Full Text :
- https://doi.org/10.1002/hbm.20467