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Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13C-caffeine breath test.
- Source :
- Journal of Gastroenterology & Hepatology; Sep2011, Vol. 26 Issue 9, p1411-1416, 6p, 2 Charts, 2 Graphs
- Publication Year :
- 2011
-
Abstract
- Background and Aim: Fibrotic progression in non-alcoholic fatty liver disease (NAFLD) is associated with impaired hepatic function. The <superscript>13</superscript>C-caffeine breath test (CBT) is a non-invasive, quantitative test of liver function. We sought to determine the utility of the CBT in detecting hepatic fibrosis in NAFLD. Methods: The CBT was applied to 48 patients with NAFLD. CBT results were compared to clinical, biochemical and histological data. Twenty-four healthy subjects served as controls. Results: Patients with simple steatosis had similar CBT values (2.28 ± 0.71 Δ‰ per 100 mg caffeine) to controls (2.31 ± 0.85, P = 1.0). However, CBT was significantly reduced in patients with non-alcoholic steatohepatitis (1.59 ± 0.65, P = 0.005) and cirrhosis (1.00 ± 0.73, P < 0.001). CBT significantly correlated with Brunt's fibrosis score ( r = −0.49, P < 0.001) but not with steatosis ( P = 0.23) or inflammation ( P = 0.08). CBT also correlated with international normalized ratio ( r = −0.61, P < 0.001), albumin ( r = 0.37, P = 0.009), aspartate aminotransferase/alanine aminotransferase ( r = −0.34, P = 0.018) and platelets ( r = 0.31, P = 0.03). On multivariate analysis, age (odds ratio 1.12, 95% confidence interval 1.042-1.203, P = 0.002) and CBT (OR 0.264, 95% CI 0.084-0.822, P = 0.02) were independent predictors of significant fibrosis ( F ≥ 2). CBT yielded an area under the receiver operating characteristic curve of 0.86 for the diagnosis of cirrhosis. Conclusions: The CBT reflects the extent of hepatic fibrosis in NAFLD and represents a non-invasive predictor of fibrosis severity in this condition. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08159319
- Volume :
- 26
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Gastroenterology & Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 64870164
- Full Text :
- https://doi.org/10.1111/j.1440-1746.2011.06760.x