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The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory.
- Source :
- Nature Neuroscience; Sep2011, Vol. 14 Issue 9, p1115-1117, 3p, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory. [ABSTRACT FROM AUTHOR]
- Subjects :
- NON-coding RNA
MEMORY
GENE silencing
LEARNING
LABORATORY mice
NEUROPLASTICITY
Subjects
Details
- Language :
- English
- ISSN :
- 10976256
- Volume :
- 14
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Nature Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 65087515
- Full Text :
- https://doi.org/10.1038/nn.2891