Anti-Inflammatory Effects of Gomisin N, Gomisin J, and Schisandrin C Isolated from the Fruit of Schisandra chinensis.

The article presents a study which investigates whether the nine major compounds of Schisandra chinensis can be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages. The lignans such as gomisin J, gomisin N and schisandrin C, have been found to reduce nitric oxide production from LPS-stimulated of Raw 264.7 cells. The Raw 264.7 cells with the three lignans reduced the expression of messenger RNA and the secretion of pro-inflammatory cytokines.