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Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 8/23/2011, Vol. 108 Issue 34, p13885-13886, 2p
- Publication Year :
- 2011
-
Abstract
- The article focuses on the use of bestatin-based activity-based probes (ABP), labeled PfA-M1 and Pf-LAP, in exploring the therapeutic potential of metallo-aminopeptidases (MAPs) in treating malaria. It notes that the probes produce varying chemotypes depending on the specificity of MAPs. Moreover, it implies that the inhibition of PfA-M1 in the Plasmodium falciparum, malaria-causing organism, causes elevation of the parasite's hemoglobin peptides.
- Subjects :
- BESTATIN
MALARIA treatment
AMINOPEPTIDASES
PLASMODIUM falciparum
PEPTIDES
HEMOGLOBINS
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 108
- Issue :
- 34
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 65170571
- Full Text :
- https://doi.org/10.1073/pnas.1105601108