Novel clinical and molecular findings in Chinese families with Hailey-Hailey disease.

The article discusses the medical condition of Chinese families with autosomal dominant disorder Hailey-Hailey disease (HHD) caused by mutations in adenosine triphosphatase (ATPase), Ca++ transporting, type 2C, member 1 (ATP2C1) gene. It discusses the linkage between HHD cases and condyloma acuminata (CA) in two Chinese families and its effect on the human secretory pathway Ca²⁺/ Mn² ± ATPase protein 1. It also presents three missense mutations in the ATP2C1 gene.