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Vitamins B status and antioxidative defense in patients with chronic hepatitis B or hepatitis C virus infection.
- Source :
- European Journal of Nutrition; Oct2011, Vol. 50 Issue 7, p499-506, 8p, 6 Charts, 1 Graph
- Publication Year :
- 2011
-
Abstract
- Background & Aims: The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon B vitamins status and antioxidative defense in infected patients was examined. Methods: Dietary record and blood levels of B vitamins and oxidative stress-associated biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV patients. Results: HBV-infected patients had significantly higher levels of total cholesterol, free fatty acids (FFA), and lower ghrelin level ( p < 0.05); and HCV-infected patients had significantly higher Ishak inflammation score and lactate dehydrogenase activity ( p < 0.05). HBV patients had significantly lower red blood cell (RBC) vitamins B and B levels, and HCV infection significantly decreased vitamins B B and folate levels in RBC and/or plasma ( p < 0.05). Correlation coefficients of RBC vitamin B versus serum FFA in HBV patients, RBC vitamins B and B versus HCV RNA and Ishak inflammation score, and plasma vitamin B vs Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had significantly higher oxidized glutathione level and lower glutathione peroxidase activity ( p < 0.05), but HCV patients had significantly lower superoxide dismutase and catalase activities ( p < 0.05). Conclusion: HBV or HCV infection enhanced oxidative stress and lowered B vitamins in circulation. In order to avoid other healthy risk, nutrition status should be monitored and limitation or supplementation of certain nutrients might be helpful for HBV- or HCV-infected patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANALYSIS of variance
BIOMARKERS
CHOLESTEROL
CHRONIC diseases
COMPARATIVE studies
DIET
FATTY acids
FOLIC acid
HEPATITIS B
HEPATITIS C
INFLAMMATION
LACTATE dehydrogenase
NUTRITIONAL assessment
NUTRITIONAL requirements
REGRESSION analysis
VITAMIN B complex
VITAMIN B2
VITAMIN B6
STATISTICAL significance
OXIDATIVE stress
GHRELIN
FOOD diaries
DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 50
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 65797412
- Full Text :
- https://doi.org/10.1007/s00394-010-0156-1